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PRE-B CELL RECEPTORS
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DeCS
Descriptor
English
:
Pre-B Cell Receptors
Descriptor
Spanish
:
Receptores de Células Precursoras de Linfócitos B
Descriptor
Portuguese
:
Receptores de Células Precursoras de Linfócitos B
Tree Number:
D12.776.124.486.485.950.750
D12.776.124.790.651.950.750
D12.776.377.715.548.950.750
D12.776.543.750.705.816.821.750
Definition
English
:
Membrane
proteins
in precursor
B-LYMPHOCYTES
(pre-B Cells). They are composed of membrane-bound MU
IMMUNOGLOBULIN HEAVY CHAINS
in complex with SURROGATE
LIGHT
CHAINS instead of conventional
IMMUNOGLOBULIN LIGHT CHAINS
. Only successful rearrangement of the VDJ segments, at the Ig heavy chain gene locus (IMMUNOGLOBULIN HEAVY CHAIN GENES), will generate mu heavy chains that can pair with surrogate
light
chains. Thus formation of the
pre-B cell receptors
is an important checkpoint in the development of mature B
cells.
History Note
English
:
2008
Allowable Qualifiers
English
:
administration & dosage
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
chemistry
classification
drug effects
deficiency
genetics
history
immunology
isolation & purification
metabolism
physiology
radiation effects
therapeutic use
ultrastructure
Record Number:
52788
Unique Identifier:
D054420
Occurrence in VHL
:
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